Best

the supreme effort one can make

the person who is most outstanding or excellent

Canadian physiologist (born in the United States) who assisted F. G. Banting in research leading to the discovery of insulin (1899-1978)

get the better of

(superlative of `good') having the most positive qualities

(comparative and superlative of `well') wiser or more advantageous and hence advisable

in a most excellent way or manner

it would be sensible

from a position of superiority or authority